教育背景:
1984-1988年,蚌埠医学院学士
1994-1996年,中山大学(原中山医科大学)硕士
1999-2002年,苏州大学博士
2002-2005年,美国University of Illinois博士后
工作经历:
1988-1999年,蚌埠医学院,血液学教研室,助教、讲师、副教授、教研室主任
2005-2011年,北京航空航天大学,“蓝天学者”特聘教授,生物与医学工程学院教授、博士生导师
2011年-至今,苏州大学“特聘教授”,苏州大学附属第一医院江苏血液研究所教授
2019年-至今,苏州大学,唐仲英医学研究院教授
研究领域:
1、血小板数量、功能调控机制及其相关疾病诊断、治疗研究。
2、血小板在心脑血管、肿瘤、感染、代谢等重大疾病中的作用及其防治研究。
团队成员:
工作人员
闫荣,博士,副研究员
赵丽丽,博士,助理研究员
刘春亮,博士,助理研究员
胡仁萍,硕士,研究实习员
博士后
田璟鸾,博士
研究生
博士研究生:肖伟玲,庞宁波,葛鑫鑫,周康熙,孙月月,Muhammad Khan
硕士研究生:张素勤,成斌,袁柳霞,杨梦楠,夏月,胡颖,孙成林
科研成果:
代表性论文:
1.Chen M,Yan R,Zhou K,Li X,Zhang Y,Liu C,Jiang M,Ye H,Meng X,Pang N,Zhao L,Liu J,Xiao W,Hu R,Cui Q,Zhong W,Zhao Y,Zhu M,Lin A,Ruan C,Dai K.Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia.Proc Natl Acad Sci U S A 2018;115(45):E10682-91.
2.Zhao L,Liu J,He C,Yan R,Zhou K,Cui Q,Meng X,Li X,Zhang Y,Nie Y,Zhang Y,Hu R,Liu Y,Zhao L,Chen M,Xiao W,Tian J,Zhao Y,Cao L,Zhou L,Lin A,Ruan C,Dai K.Protein kinase A determines platelet lifespan and survival by regulating apoptosis.Journal of Clinical Investigation 2017;127(12):4338-51.
3.Zhang Y,Zhang J,Yan R,Tian J,Zhang Y,Zhang J,Chen M,Cui Q,Zhao L,Hu R,Jiang M,Li Z,Ruan C,He S,Dai K.Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis.Proc Natl Acad Sci U S A 2017;114(11):2964-69.
4.Liu L,Chen M,Zhao L,Zhao Q,Hu R,Zhu J,Yan R,Dai K.Ethanol Induces Platelet Apoptosis.Alcoholism:Clinical and Experimental Research 2017;41(2):291–298.
5.Zhao Q,Li M,Chen M,Zhou L,Zhao L,Hu R,Yan R,Dai K.Lovastatin induces platelet apoptosis.Environmental Toxicology and Pharmacology 2016;42:69-75.
6.Yan R,Chen M,Ma N,Zhao L,Cao L,Zhang Y,Zhang J,Yu Z,Wang Z,Xia L,Ruan C,Dai K.Glycoprotein Ibαclustering induces macrophage-mediated platelet clearance in the liver.Thrombosis and Haemostasis 2015;113(1):107-17.
7.Zhao L,Lu G,Zhao Q,Zhang M,Chen M,Zhang J,Dai K.Staurosporine Induces Platelet Apoptosis Through p38 Mitogen-Activated Protein Kinase Signaling Pathway.Clin Lab 2015;61(7):717-26.
8.Li J,Dai K,Wang Z,Cao L,Bai X,Ruan C.Platelet functional alterations in a Bernard-Soulier syndrome patient with filamin A mutation.J Hematol Oncol.2015;8:79.
9.Wu Y,Dai J,Zhang W,Yan R,Zhang Y,Ruan C,Dai K.Arsenic trioxide induces platelet apoptosis.PLoS One 2014;9(1):e86445.
10.Zhang J,Chen M,Zhang Y,Zhao L,Yan R,Dai K.Carmustine induces platelet apoptosis.Platelets 2015;26(5):437-42
11.Li M,Wang Z,Ma T,Lu G,Yan R,Zhao L,Deng K,Dai K.Enhanced platelet apoptosis in chronic uremic patients.Renal Failure 2014;36:847-53.
12.Pan Y,Yago T,Fu J,Herzog B,McDaniel J,MehtaD'Souza P,Cai X,Ruan C,McEver J,West C,Dai K,Chen H,Xia L.Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets.Blood 2014;124(24):3656-65.
13.Shou LM,Zhang QY,Li W,Xie X,Chen K,Lian L,Li ZY,Gong FR,Dai KS,Mao YX,Tao M.Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation ofα2 integrin.Oncol Rep 2013;30(3):1059-66.
14.Zhang P,Du J,Zhao L,Wang X,Zhang Y,Yan R,Dai J,Liu G,Zhang F,Dai K.The role of intraplatelet reactive oxygen species in the regulation of platelet glycoprotein Ibαectodomain shedding.Thrombosis Research 2013;132(6):696-701.
15.Zhao L,Zhang W,Chen M,Zhang J,Zhang M,Dai K.Aspirin induces platelet apoptosis.Platelets 2013;24(8):637-42.
16.Zhang W,Zhao L,Liu J,Du J,Yan R,Dai K.Role of 14-3-3ζin Platelet Glycoprotein Ibα-von Willebrand Factor Interaction-Induced Signaling.International Journal of Molecular Sciences 2012;13:5364-74.
17.Zhang W,Zhao L,Liu J,Du J,Wang Z,Ruan C,Dai K.Cisplatin induces platelet apoptosis through the ERK signaling pathway.Thrombosis Research 2012;13:81-91.
18.Yan R,Mo X,Paredes AM,Dai K,Lanza F,Cruz MA,Li R.Reconstitution of the Platelet Glycoprotein Ib-IX Complex in Phospholipid Bilayer Nanodiscs.Biochemistry 2011;50(49):10598-606.
19.Zhang W,Liu J,Sun R,Zhao L,Du J,Ruan C,Dai K.Calpain Activator Dibucaine Induces Platelet Apoptosis.International Journal of Molecular Sciences 2011;12:2125-37.
20.Li S,Wang Z,Liao Y,Zhang W,Shi Q,Yan R,Ruan C,Dai K.The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis.Journal of Thrombosis and Haemostasis 2010;8:341-50.
21.Wang Z,Shi Q,Yan R,Liu G,Zhang W,Dai K.The role of calpain in the regulation of ADAM17-dependent GPIb ectodomain shedding.Archives of Biochemistry and Biophysics 2010;495:136-43.
22.Li S,Shi Q,Liu G,Zhang W,Wang Z,Wang Y,Dai K.Mechanism of platelet functional changes and the effects of anti-platelet agents on in vivo hemostasis under different gravity conditions.Journal of Applied Physiology 2010;108:1241-49.
23.Wang Z,Shi Q,Li S,Du J,Liu J,Dai K.Hyperthermia induces platelet apoptosis and glycoprotein Ibαectodomain shedding.Platelets 2010;21:229-37.
24.Wang Z,Li S,Shi Q,Yan R,Liu G,Dai K.Calmodulin antagonists induce platelet apoptosis.Thrombosis Research 2010;125:340-50.
25.Li G,Qu L,Meng G,Bai X,Dai K,Zheng X.Crystallization and preliminary X-ray crystallographic studies of human FAIM protein.Acta Crystallogr Sect F Struct Biol Cryst Commun 2010;66(Pt 8):935-7.
26.Yuan Y,Zhang W,Yan R,Liao Y,Zhao L,Ruan C,Du X,Dai K.Identification of a novel 14-3-3ζbinding site within the cytoplasmic domain of platelet glycoprotein Iba that plays a key role in regulating the VWF binding function of glycoprotein Ib-IX.Circulation Research 2009;105:1177-85.
27.Dai K,Wang Y,Yan R,Shi Q,Wang Z,Yuan Y,Cheng H,Li S,Fan Y,Zhuang F.Effects of microgravity and hypergravity on platelet function.Thrombosis and Haemostasis 2009;101:902-10.(Cover,Editorial focus)
28.Cheng H,Yan R,Li S,Yuan Y,Liu J,Ruan C,Dai K.Shear-induced von Willebrand factor-dependent platelet glycoprotein Ibαshedding.The American Journal of Physiology-Heart and Circulatory Physiology 2009;297:H2128-35.
29.Yan R,Wang Z,Yuan Y,Cheng H,Dai K.Role of cAMP-dependent protein kinase in the regulation of platelet procoagulant activity.Archives of Biochemistry and Biophysics 2009;485:41-8.
30.Yan R,Li S,Dai K.The critical roles for cyclic AMP/cyclic AMP-dependent protein kinase in platelet physiology.Frontiers of Biology in China,2009;4:7-14.
31.Dai K,Yan R,Li S,Fan Y,Zhuang F,Ruan C.Prolonged inhibition of protein kinase A results in the dysfunction of platelet by GPIba shedding.Thrombosis Research 2009;124:101-9.
32.Li G,Tang Z,Meng G,Dai K,Zhao J,Zheng X.Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120.Acta Cryst Structural Biology and Crystallization Communications 2009;F65:1039-41.
33.Li S,Shi Q,Wang Z,Yan R,Cheng H,Dai K.Hypergravity Results in Human Platelet Hyperactivity.Journal of Physiology and Biochemistry 2009;65:147-56.
34.Dai K,Bodnar R,Berndt MC,Du X.A critical role for 14-3-3 protein in platelet adhesion and its therapeutic implications.Blood 2005;106:1975-81.
35.Dai K,Zhu H,Ruan C.Generation and characterization of recombinant single chain Fv antibody that recognizes platelet glycoprotein Ibalpha.Thrombosis Research 2003;109:137-44.
36.Dai K,Gao W,Ruan C.The Sma I polymorphism in the von Willebrand factor gene associated with acute ischemic stroke.Thrombosis Research 2001;104:389-95.
著作:
1.董尔丹,张幼仪,戴克胜等,《血管生物学》,第二版,北京大学医学出版社,2014年。
2.阮长耿,戴克胜等,主编,《中国工程科技论坛:血栓与血管生物学前沿》,高等教育出版社,2013年。
3.侯明,戴克胜,彭军,主编,《血小板疾病》,第二版,科技文献出版社,2012年。
主要学术任职:
1.国际宇航科学院院士
2.中国生理学会血栓与止血专业委员会主任委员
3.中国病生理学会微循环专业委员会主任委员
4.中国中西医结合微循环专业委员会主任委员
5.中国微循环学会痰瘀专业委员会副主任委员
6.中国医药质量管理协会临床试验及大数据质量管理分会常务委员
7.世界中医药联合会气血专业委员会常务理事
8.中华血液学分会血栓与止血学组委员
9.中国病生理学会实验血液学专业委员会血管生物学组副组长
10.《Frontiers of Biology in China》杂志编委
11.《中华现代临床医学杂志》杂志编委
12.《血栓与止血学》杂志编委
13.《World Journal of Traditional Chinese Medicine》杂志编委